Tenofovir DF

Tenofovir DF is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older. Tenofovir DF is always used in combination with other HIV medicines...

Before taking tenofovir DF, tell your health care provider:

• If you are allergic to tenofovir DF or any other medicines.
• If you have or have ever had liver problems, including HBV infection.
• If you have or have ever had kidney problems.
• If you have or have ever had bone problems.
• If you have or have ever had any other medical conditions.
• If you are pregnant or plan to become pregnant. Whether tenofovir DF can harm an unborn baby is unknown. Tenofovir DF should be used during pregnancy only if clearly needed. Talk to your health care provider about possible risks with taking tenofovir DF when pregnant.
• If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking tenofovir DF.
• If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the AIDSinfo HIV and Birth Control infographic.
• About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Tenofovir DF may affect the way other medicines or products work, and other medicines or products may affect how tenofovir DF works. Taking tenofovir DF together with certain medicines or products may cause serious, life-threatening side effects.
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Tenofovir DF belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Tenofovir disoproxil fumarate (tenofovir DF) can cause serious, life-threatening side effects. These include a buildup of lactic acid in the blood (lactic acidosis) and severe liver problems.

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