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Pegasys interferon therapy II



Sustained Response in HBeAg Negative Chronic Hepatitis B Patients 3 Years After Treatment with Pegasys

Investigators with the international Peginterferon alfa-2a in HBeAg-negative
Chronic Hepatitis B Study Group randomly assigned more than 500 HBeAg negative chronic hepatitis B patients to received 180 mcg/week pegylated interferon monotherapy, 100 mg/day lamivudine (Epivir) monotherapy, or the same doses of both drugs used in combination, all for 48 weeks.

The researchers previously reported that HBeAg negative patients treated with pegylated interferon, with or without lamivudine, achieved significantly higher rates of sustained response 6 months after completing therapy than individuals treated with lamivudine alone.
In the present analysis, the authors looked at long-term durability though 3 years after treatment completion. A total of 315 patients (59% of the original patient population) participated in the post-treatment observational study.
Results
-3 years after treatment, 28% of patients treated with pegylated interferon (with or without lamivudine) had HBV DNA levels <10,000 copies/mL, compared to 15% of patients treated with lamivudine monotherapy (P = 0.039).
-Similarly, more patients treated with pegylated interferon had normal alanine aminotransferase (ALT) at the end of follow-up compared to those treated with lamivudine monotherapy (31% vs 18%; P = 0.032).
-Use of pegylated interferon and high baseline ALT were independent predictors of long-term virological response (P = 0.040 and 0.01, respectively).
-Among participants treated with pegylated interferon (again, with or without lamivudine), 8.7% overall -- or 44% of those with undetectable HBV at the end of follow-up -- cleared hepatitis B surface antigen (HBsAg), versus none treated with lamivudine monotherapy.
Based on these findings, the study authors concluded, "Biochemical and virologic responses were sustained for <3 years in approximately 25% of patients given a 48-week course of peginterferon alpha-2a, with or without lamivudine."
In their discussion, they added, "The ability to induce HBsAg clearance -- an outcome that is associated with long-term complication-free survival -- supports the use of peginterferon alfa-2a as a first-line treatment of HBeAg negative disease, avoiding the need for long-term therapy and the associated risks of developing drug resistance in those patients who achieve and maintain their response."
Drug resistance is a known risk with lamivudine and other nucleoside/nucleotide analogs that directly target HBV. Interferon is less likely to be limited by resistance since it promotes immune response against HBV rather than interfering directly with the viral life-cycle.
tags:Pegasys interferon therapy,Similarly,HBeAg negative disease

treatment for chronic hepatitis




Specific treatment for chronic hepatitis will be determined by your physicians based on:
  • your overall health and medical history
  • extent of the disease
  • your tolerance for specific medications, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference
Treatment of chronic hepatitis depends on the underlying cause of the disease. The goal of treatment is to stop damage to the liver and alleviate symptoms.
Treatment may include one/more of the following:
Antiviral Agent - When caused by hepatitis B or C, inflammation of the liver may be stopped with the antiviral agent interferon-alpha.
Corticosteroids - Corticosteroids may be used to treat chronic liver disease caused by an autoimmune disorder. Inflammation is suppressed, but scarring of the liver may continue.
Discontinuation of certain drugs - When chronic hepatitis is caused by certain drugs, discontinuing those drugs usually clears up any symptoms.
Preventing the spread of viral hepatitis:
Proper hygiene is the key to preventing the spread of many diseases, including hepatitis. Other preventive measures include:
  • vaccinations - A hepatitis B vaccine is routinely given to toddlers as part of their immunization schedule. A hepatitis A vaccine is available for people at risk for contracting the disease while traveling. (There are no vaccines for hepatitis C, D, or E at this time.)
  • blood transfusion - Blood transfusions are routinely screened for Hepatitis B and C to reduce the risk of infection.
  • antibody preparation - If a person has been exposed to hepatitis, an antibody preparation can be administered to help protect them from contracting the disease.treatment


tags:treatment for chronic hepatitis,liver,vaccinations - A hepatitis B vaccine,When caused by hepatitis,



Cleaning the liver


Here is a good combination of herbs that are excellent for cleaning the liver, which is usually in a capsule form:Dandelion Root, Turmeric Root, Parsley Leaves,Chamomile Flower, Gentian Root Blessed Thistle Herb, Angelica , Angelica Root and Goldenrod Herb.
Product for maintaining your liver, especially if it is congested with excessive drinking is Milk Thistle which is well known to help treat cirrhosis .

Your liver is the filter of everything you digest so cleansing it and your digestive system is very important.

tags:cleaning the live, Milk Thistle

Liver cleanse



Cleansing the liver of gall stones dramatically improves digestion which is the basis of your whole health. You can expect many or all of your allergies to disappear, too, more and more with each subsequent cleanse. Each liver cleanse "cures" a different set of allergies, suggesting that the liver is compartmentalized - different parts having different duties. It follows that by getting all the stones out, all allergies will disappear! Well - incredibly, a liver cleanse has eliminated shoulder, upper arm and upper back pain.

Preparation:
Cleansing the liver bile ducts is the most powerful procedure you can undertake in order to improve your body's health. A liver cleanse should be done twice a year if possible. Ideally, it should be part of a semi-annual liver/parasite cleanse the sequence of which enhances the overall results.
Phase I (optional): Though some are not sensitive to amalgam fillings, those that are may do any dental work first, if possible. Your mouth should be metal free and bacteria free and all cavitations should have been cleaned. A toxic mouth can put a heavy load on the liver, burdening it immediately after cleansing. Eliminate any tooth problem first for best results. If this is not possible then go to the liver cleanse anyway.
Phase II (also optional): Completing a parasite cleanse before cleansing the liver is also highly recommended but not mandatory. You want your kidneys, bladder and urinary tract in top condition so they can efficiently remove any substances incidentally absorbed from the intestines as the bile is being secreted.
Parasite. Dr. Hulda Clark maintains that you can't clean a liver with living parasites in it and that you won't get as many stones out, and you may feel quite sick. While this is Dr. Clark’s recommendation, it is to me an "ideal" situation. We have seen many copious stone discharges without the parasite cleanse prior to the liver cleanse.

Liver cleanse ingredients:
Epsom salts 4 table spoons (not less !!!)
Olive oil 3/4 of a cup (light olive oil is easier to get down, use only the best cold pressed virgin oil). Bariani is a good one.
Fresh grapefruit and lemons. Do not use concentrate or store-bought juice. Make your own. Enough to squeeze 1/4 cup of lemon and 1/2 cup of grapefruit juice.
Ornithine (optional)4 to 8, to be sure you can sleep. Suitable jar with non-metallic lid. Shake your mixture well and gulp it down 1/2 cup of lemon/grapefruit juice Use a couple of ounces of this juice each time to help get down the
Epsom salt solution (four feedings) if desired...
Procedure

Liver Flush: Cleansing Liver and Gallbladder For Better Health
Large Cholesterol Gallstone
Click on this image to see more photos like this one
Liver and Gallbladder Anatomy
IMPORTANT!:Liver cleansing recipe is the same as gall bladder cleansing recipe!
Cleansing of both organs is achieved by the same procedure!
Liver flush - Use of Colander
Gallstones, Liver, Gallbladder, Kidney Cleanse...


tags:liver with living parasites ,

liver cleanse,Liver cleansing recipe ,

Hepatitis B



Hepatitis B virus causes a life-threatening liver infection that often leads to chronic liver disease and puts people at high risk of death from cirrhosis of the liver and liver cancer. Hepatitis B virus infection is a major global health problem. Worldwide, an estimated two billion people have been infected with the hepatitis B virus (HBV), and more than 350 million have chronic (long-term) liver infections.
A vaccine against hepatitis B has been available since 1982. Hepatitis B vaccine is 95% effective in preventing HBV infection and its chronic consequences, and is the first vaccine against a major human cancer. 

The vaccine has an outstanding record of safety and effectiveness. Since 1982, over one billion doses of hepatitis B vaccine have been used worldwide. In many countries where 8% to 15% of children used to become chronically infected with HBV, vaccination has reduced the rate of chronic infection to less than 1% among immunized children.
As at December 2007, 171 countries reported that they had included the hepatitis B vaccine into their national infant immunization programmes (two of these countries reported introducing in part of the country only). 
This is a major increase compared with 31 countries in 1992, the year that the World Health Assembly passed a resolution to recommend global vaccination against hepatitis B.

tags:hepatitis B,virus,


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